SCHEMBL6234428

SCHEMBL6234428

CC(C)C[C@H](SC1(N2CCNCC2)C=CC(c2ccccc2)=CC1)C(=O)NCC#N

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CTSS P25774 16/20 0.46
CTSL P07711 15/20 0.46
CTSB P07858 14/20 0.46
CTSK P43235 13/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6234526 0.88 CTSL (0.37) CTSSCTSLCTSBCTSK
SCHEMBL6209080 0.79 CTSS (0.44) CTSSCTSLCTSBCTSK
SCHEMBL6234426 0.74 CTSL (0.43) CTSSCTSLCTSBCTSK
SCHEMBL6235381 0.73 CTSK (0.40) CTSSCTSLCTSBCTSK
SCHEMBL6239203 0.71 CTSB (0.47) CTSSCTSLCTSBCTSK
SCHEMBL6216512 0.68 CTSS (0.47) CTSSCTSLCTSBCTSK
SCHEMBL4702233 0.67 CTSL (0.66) CTSSCTSLCTSBCTSK
SCHEMBL4699654 0.67 CTSL (0.71) CTSSCTSLCTSBCTSK
SCHEMBL4700174 0.67 CTSL (0.71) CTSSCTSLCTSBCTSK
SCHEMBL4699490 0.67 CTSL (0.71) CTSSCTSLCTSBCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1372655-A4 CATHEPSIN CYSTEINE PROTEASE INHIBITORS MERCK FROSST CANADA INC (CA) 2005-10-12 EP claimed
EP-1372655-A2 CATHEPSIN CYSTEINE PROTEASE INHIBITORS Merck Frosst Canada & Co. (CA) 2004-01-02 EP claimed
WO-2002069901-A2 CATHEPSIN CYSTEINE PROTEASE INHIBITORS MERCK FROSST CANADA & CO. (CA) 2002-09-12 WO claimed