Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 2/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636939 | 0.72 | HTR4 (0.39) | ERCC1ERCC5FEN1ERCC4ADORA2B | |
| SCHEMBL7856402 | 0.72 | HTR4 (0.40) | ERCC1ERCC5FEN1ERCC4ADORA2B | |
| SCHEMBL13641556 | 0.65 | ADORA1 (0.41) | ERCC1ERCC5FEN1ERCC4ADORA2B | |
| SCHEMBL6260462 | 0.64 | ADORA2B (0.40) | ERCC1ERCC5FEN1ERCC4ADORA2B | |
| SCHEMBL6513423 | 0.64 | ERCC1 (0.63) | ERCC1ERCC5FEN1ERCC4ADORA2B | |
| SCHEMBL11580726 | 0.61 | KMT2A (0.42) | MAPTLMNAHSD17B10POLBALDH1A1 | |
| SCHEMBL3300277 | 0.61 | ALDH1A1 (0.49) | ERCC1FEN1ERCC4LMNAHSD17B10 | |
| SCHEMBL4508217 | 0.61 | ALDH1A1 (0.42) | MAPTLMNAPOLBALDH1A1EGLN1 | |
| SCHEMBL31223899 | 0.60 | LMNA (0.36) | ERCC1ERCC5FEN1ERCC4ADORA2B | |
| SCHEMBL20631025 | 0.60 | FEN1 (0.44) | ERCC1ERCC5FEN1ERCC4ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530467-A2 | COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB | Warner-Lambert Company LLC (US) | 2005-05-18 | — | — | EP | disclosed |
| WO-2004006912-A2 | COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB | WARNER-LAMBERT COMPANY LLC (US) | 2004-01-22 | — | — | WO | disclosed |