Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | GFER | P55789 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 2/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6271695 | 0.72 | KDM4E (0.41) | KDM4ERAD52HTTALDH1A1CNR2 | |
| SCHEMBL6604741 | 0.72 | KDM4E (0.45) | KDM4ERAD52HTTALDH1A1NPC1 | |
| SCHEMBL6231516 | 0.72 | KDM4E (0.43) | KDM4ERAD52HTTALDH1A1KMT2A | |
| SCHEMBL6258152 | 0.71 | KDM4E (0.40) | KDM4ERAD52HTTALDH1A1KMT2A | |
| SCHEMBL6232949 | 0.70 | KDM4E (0.41) | KDM4ERAD52HTTALDH1A1TDP1 | |
| SCHEMBL6231518 | 0.69 | KDM4E (0.43) | KDM4ERAD52HTTALDH1A1RAB9A | |
| SCHEMBL18960395 | 0.69 | NTRK1 (0.42) | KDM4ERAD52HTTKMT2ACNR2 | |
| SCHEMBL17487511 | 0.69 | CXCL8 (0.53) | KDM4ERAD52HTTALDH1A1KMT2A | |
| SCHEMBL623760 | 0.65 | KDM4E (0.66) | KDM4ERAD52HTTALDH1A1RAB9A | |
| SCHEMBL6420487 | 0.65 | KDM4E (0.50) | KDM4ERAD52HTTALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004092181-A9 | HETEROCYCLIC MCHR1 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-01-27 | — | — | WO | disclosed |