Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28054067 | 0.98 | ALDH1A1 (0.56) | ALDH1A1MAPTKMT2AGRM1MEN1 | |
| SCHEMBL7401619 | 0.85 | PARP1 (0.46) | ALDH1A1MAPTCYP1A2KDM4EHSD17B10 | |
| SCHEMBL4012969 | 0.85 | ALDH1A1 (0.62) | ALDH1A1MAPTKMT2AGRM1MEN1 | |
| Hydrochloric Acid SCHEMBL1416836 | 0.83 | ALDH1A1 (0.61) | ALDH1A1MAPTKMT2AGRM1MEN1 | |
| Hydrochloric Acid SCHEMBL7965036 | 0.83 | PARP1 (0.44) | ALDH1A1MAPTCYP1A2KDM4EHSD17B10 | |
| SCHEMBL2345304 | 0.82 | HCAR3 (0.57) | ALDH1A1MAPTKMT2AGRM1MEN1 | |
| SCHEMBL1002161 | 0.82 | MAPT (0.69) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL3272963 | 0.81 | MAPT (0.50) | ALDH1A1MAPTKMT2AMEN1TDP1 | |
| Hydrochloric Acid SCHEMBL19306177 | 0.80 | MAPT (0.49) | ALDH1A1MAPTKMT2AMEN1TDP1 | |
| SCHEMBL31202243 | 0.80 | MAPT (0.61) | ALDH1A1MAPTKMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007632-A1 | SUBSTITUTED PYRIDAZINONES AS INHIBITORS OF P38 | PHARMACIA CORPORATION (US) | 2005-01-27 | — | — | WO | disclosed |
| US-20050020594-A1 | Substituted pyridazinones | PHARMACIA CORPORATION | 2005-01-27 | — | — | US | disclosed |
| CN-1127487-C | Phthalazinones | ALTANA PHARMA AG (DE) | 2003-11-12 | — | — | CN | disclosed |
| CN-1249749-A | Phthalazinones | BYK GULDEN LOMBERC CHEM FAB GM (DE) | 2000-04-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020594-A1 | Substituted pyridazinones | MAP4K2, MAPK6, MAP3K6 | ALDH1A1 2217/4885MAPT 1544/4885KMT2A 4449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.