Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 16/20 | 0.59 |
| ▸ | MMP1 | P03956 | 15/20 | 0.58 |
| ▸ | MMP13 | P45452 | 9/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239853 | 0.92 | ADAM17 (0.51) | ADAM17MMP1MMP13 | |
| SCHEMBL6241443 | 0.91 | ADAM17 (0.56) | ADAM17MMP1MMP13 | |
| SCHEMBL6238120 | 0.91 | ADAM17 (0.51) | ADAM17MMP1MMP13 | |
| SCHEMBL6242757 | 0.89 | MMP1 (0.59) | ADAM17MMP1MMP13 | |
| SCHEMBL6239672 | 0.86 | ADAM17 (0.44) | ADAM17MMP1MMP13 | |
| SCHEMBL6238495 | 0.85 | ADAM17 (0.71) | ADAM17MMP1MMP13 | |
| SCHEMBL6244941 | 0.84 | ADAM17 (0.59) | ADAM17MMP1MMP13S1PR1S1PR5 | |
| SCHEMBL6238727 | 0.84 | MMP1 (0.54) | ADAM17MMP1MMP13 | |
| SCHEMBL6237935 | 0.84 | MMP1 (0.52) | ADAM17MMP1MMP13 | |
| SCHEMBL6238179 | 0.84 | MMP1 (0.54) | ADAM17MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104412-B1 | TACE INHIBITORS | PFIZER PROD INC (US) | 2005-06-15 | — | — | EP | claimed |