Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL79022 | 0.76 | KDM4E (0.39) | KDM4EPKMHSD11B1PDK2GAA | |
| Hydrochloric Acid SCHEMBL349115 | 0.74 | KDM4E (0.38) | KDM4EPKMHSD11B1PDK2GAA | |
| SCHEMBL28346505 | 0.73 | OXTR (0.33) | KDM4EPKMGAAMAPTOXTR | |
| SCHEMBL6544857 | 0.73 | KDM4E (0.37) | KDM4EPKMHSD11B1PDK2GAA | |
| SCHEMBL30990090 | 0.73 | KDM4E (0.37) | KDM4EPKMHSD11B1PDK2GAA | |
| SCHEMBL18242928 | 0.73 | OXTR (0.33) | HSD11B1GAAMAPTOXTR | |
| SCHEMBL29842453 | 0.70 | GAA (0.36) | KDM4EPKMHSD11B1GAAMAPT | |
| SCHEMBL2287265 | 0.70 | GAA (0.36) | KDM4EPKMHSD11B1GAAMAPT | |
| SCHEMBL6544607 | 0.70 | KDM4E (0.39) | KDM4EPKMHSD11B1GAAMAPT | |
| SCHEMBL2708889 | 0.68 | KDM4E (0.34) | KDM4EPKMGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936636-B2 | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity | ALLERGAN, INC. (US) | 2005-08-30 | — | — | US | disclosed |
| WO-2005000784-A2 | 5-[PHENYL, TETRAHYDRONAPHTHALENE-2-YL DIHYDRONAPHTHALEN-2-YL AND HETEROARYL- CYCLOPROPYL]-PENTADIENOIC ACID DERIVATIVES HAVING SERUM GLUCOSE REDUCING ACTIVITY | ALLERGAN, INC. (US) | 2005-01-06 | — | — | WO | disclosed |
| US-20050004213-A1 | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity | ALLERGAN, INC. | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004213-A1 | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity | PNLIP, TPO, MTTP | KDM4E 3712/4885PKM 1806/4885HSD11B1 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.