Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 3/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.43 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239925 | 0.84 | SRD5A2 (0.50) | SRD5A2AKR1B1NR3C1PTGS1NR1H4 | |
| SCHEMBL6239365 | 0.83 | SRD5A2 (0.49) | SRD5A2AKR1B1NR3C1PTGS1NR1H4 | |
| SCHEMBL10885686 | 0.78 | LMNA (0.47) | SRD5A2AKR1B1NR1H4ALDH1A1MAPT | |
| SCHEMBL6241535 | 0.77 | CARM1 (0.56) | SRD5A2AKR1B1NR3C1PTGS1NR1H4 | |
| SCHEMBL6235731 | 0.75 | SRD5A2 (0.64) | SRD5A2AKR1B1NR3C1PTGS1AKR1C3 | |
| SCHEMBL1145770 | 0.74 | SRD5A2 (0.83) | SRD5A2AKR1B1NR3C1PTGS1GAA | |
| SCHEMBL10745159 | 0.74 | KDM4E (0.57) | ALDH1A1POLBKDM4EGLAGAA | |
| SCHEMBL3635012 | 0.74 | CYP2A6 (0.58) | ALDH1A1MAPTHPGDHSD17B10TDP1 | |
| SCHEMBL21243832 | 0.72 | SRD5A2 (0.72) | SRD5A2AKR1B1NR3C1PTGS1AKR1C3 | |
| SCHEMBL2999416 | 0.72 | SRD5A2 (0.72) | SRD5A2AKR1B1NR3C1PTGS1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009104-A2 | BENZOIC AND PHENYL ACETIC ACID DERIVATIVES AS HNF-4 MODULATORS | LIGAND PHARMACUETICALS INCORPORATED (US) | 2005-02-03 | — | — | WO | claimed |
| WO-2005009104-A2 | BENZOIC AND PHENYL ACETIC ACID DERIVATIVES AS HNF-4 MODULATORS | LIGAND PHARMACUETICALS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |