Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.50 |
| ▸ | THRA | P10827 | 5/20 | 0.48 |
| ▸ | THRB | P10828 | 5/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237474 | 0.84 | SRD5A2 (0.50) | SRD5A2AKR1B1NR3C1NR1H4ALDH1A1 | |
| SCHEMBL6239365 | 0.83 | SRD5A2 (0.49) | SRD5A2THRATHRBAKR1B1NR3C1 | |
| SCHEMBL6241535 | 0.77 | CARM1 (0.56) | SRD5A2AKR1B1NR3C1NR1H4ALDH1A1 | |
| SCHEMBL10885686 | 0.75 | LMNA (0.47) | SRD5A2THRATHRBAKR1B1NR1H4 | |
| SCHEMBL6235731 | 0.75 | SRD5A2 (0.64) | SRD5A2AKR1B1NR3C1NR1H4POLB | |
| SCHEMBL1145770 | 0.74 | SRD5A2 (0.83) | SRD5A2AKR1B1NR3C1GAAABCC4 | |
| SCHEMBL21243832 | 0.72 | SRD5A2 (0.72) | SRD5A2THRATHRBAKR1B1NR3C1 | |
| SCHEMBL2999416 | 0.72 | SRD5A2 (0.72) | SRD5A2THRATHRBAKR1B1NR3C1 | |
| SCHEMBL3586863 | 0.71 | KDM4E (0.67) | AKR1B1ALDH1A1MAPTGAAKDM4E | |
| SCHEMBL7189113 | 0.70 | FFAR1 (0.57) | SRD5A2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009104-A2 | BENZOIC AND PHENYL ACETIC ACID DERIVATIVES AS HNF-4 MODULATORS | LIGAND PHARMACUETICALS INCORPORATED (US) | 2005-02-03 | — | — | WO | claimed |
| WO-2005009104-A2 | BENZOIC AND PHENYL ACETIC ACID DERIVATIVES AS HNF-4 MODULATORS | LIGAND PHARMACUETICALS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |