Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237291 | 0.76 | CYP17A1 (0.46) | GSK3BIRAK4PIM1PIM3PIM2 | |
| SCHEMBL6071515 | 0.73 | GSK3B (0.63) | GSK3B | |
| SCHEMBL6390136 | 0.72 | ALDH1A1 (0.48) | — | |
| SCHEMBL6277293 | 0.70 | XDH (0.43) | — | |
| SCHEMBL6274665 | 0.67 | CCR1 (0.36) | — | |
| SCHEMBL6071445 | 0.66 | GSK3B (0.55) | GSK3BMAP4K1 | |
| SCHEMBL6071785 | 0.66 | GSK3B (0.55) | GSK3BMAP4K1 | |
| SCHEMBL10515677 | 0.65 | NPC1 (0.57) | IRAK4 | |
| SCHEMBL6071421 | 0.64 | KMT2A (0.51) | GSK3BMAP4K1IRAK4 | |
| SCHEMBL6253146 | 0.63 | GSK3B (0.40) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1523314-A2 | PYRAZOLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-04-20 | — | — | EP | disclosed |
| WO-2004009597-A2 | PYRAZOLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |