Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.36 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.33 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
| ▸ | SMO | Q99835 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6225827 | 0.82 | NPBWR1 (0.39) | CCR1KCNK2LMNANPC1RAB9A | |
| SCHEMBL6253146 | 0.79 | GSK3B (0.40) | LMNAKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL6278086 | 0.78 | GSK3B (0.49) | LMNAKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL6390136 | 0.78 | ALDH1A1 (0.48) | LMNAKDM4ENPC1POLBRAB9A | |
| SCHEMBL8344682 | 0.74 | MAPT (0.64) | KCNK2LMNAKDM4ENPC1POLB | |
| SCHEMBL6277293 | 0.73 | XDH (0.43) | LMNAKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL6237563 | 0.67 | GSK3B (0.43) | — | |
| SCHEMBL8344605 | 0.67 | LMNA (0.52) | KCNK2LMNAKDM4ENPC1RAB9A | |
| SCHEMBL6204920 | 0.66 | KMT2A (0.66) | LMNAKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL12844296 | 0.65 | MPO (0.49) | LMNAKDM4ERAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |