SCHEMBL6237880

SCHEMBL6237880

O=C(OCc1ccccc1)c1cc2c(=O)n(CCc3ccccc3CS(=O)(=O)c3ccccc3)c(=O)[nH]c2s1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.39
MMP13 P45452 1/20 0.38
FEN1 P39748 3/20 0.37
HSD17B10 Q99714 2/20 0.34
TSHR P16473 1/20 0.34
ALDH1A1 P00352 2/20 0.34
GAA P10253 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
HDAC8 Q9BY41 2/20 0.34
HDAC6 Q9UBN7 2/20 0.34
ADORA2B P29275 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC11 Q96DB2 1/20 0.34
CDK5 Q00535 1/20 0.34
CDK5R1 Q15078 1/20 0.34
MMP2 P08253 2/20 0.33
MMP9 P14780 2/20 0.33
MMP12 P39900 2/20 0.33
TP53 P04637 1/20 0.33
MMP1 P03956 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7025417 0.83 ADORA2B (0.40) MAPTMMP13HSD17B10TSHRALDH1A1
SCHEMBL7018700 0.81 SMN1; SMN2 (0.46) MAPTMMP13HSD17B10ALDH1A1GAA
SCHEMBL6237878 0.80 MMP13 (0.40) MAPTMMP13HSD17B10TSHRALDH1A1
SCHEMBL6258644 0.80 MMP13 (0.54) MAPTMMP13TSHRALDH1A1GAA
SCHEMBL7021004 0.79 L3MBTL1 (0.46) MAPTMMP13HSD17B10ALDH1A1GAA
SCHEMBL16637307 0.77 HSD17B10 (0.52) MAPTHSD17B10TSHRALDH1A1GAA
SCHEMBL6236551 0.77 ADORA2B (0.39) MAPTMMP13HSD17B10ALDH1A1GAA
SCHEMBL6237223 0.75 TSHR (0.42) MAPTMMP13HSD17B10TSHRALDH1A1
SCHEMBL7145713 0.75 MMP13 (0.43) MAPTMMP13HSD17B10ALDH1A1GAA
SCHEMBL6235404 0.75 SMN1; SMN2 (0.52) MAPTHSD17B10ALDH1A1GAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1530475-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
EP-1530467-A2 COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
WO-2004006931-A2 PHARMACEUTICAL COMPOSTIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed
WO-2004006912-A2 COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed