Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7021004 | 0.88 | L3MBTL1 (0.46) | SMN1; SMN2HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL7025417 | 0.87 | ADORA2B (0.40) | SMN1; SMN2HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL6236551 | 0.86 | ADORA2B (0.39) | SMN1; SMN2HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL16637307 | 0.85 | HSD17B10 (0.52) | SMN1; SMN2TP53MAPTADORA2BALDH1A1 | |
| SCHEMBL6258644 | 0.84 | MMP13 (0.54) | SMN1; SMN2LMNAKMT2AMEN1MMP13 | |
| SCHEMBL6235404 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNANPSR1KMT2AHDAC1 | |
| SCHEMBL6729780 | 0.82 | MMP13 (0.41) | SMN1; SMN2LMNANPSR1KMT2AMEN1 | |
| SCHEMBL6237880 | 0.81 | MAPT (0.39) | SMN1; SMN2KMT2AHDAC1HDAC11HDAC8 | |
| SCHEMBL6473178 | 0.79 | KDM4E (0.49) | SMN1; SMN2LMNANPSR1KMT2AMEN1 | |
| SCHEMBL6237223 | 0.79 | TSHR (0.42) | SMN1; SMN2KMT2AMEN1MMP13TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370562-A1 | THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-17 | — | — | EP | claimed |
| WO-2002064598-A1 | THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |