SCHEMBL6237885

SCHEMBL6237885

COc1ccc2oc(C(=O)NC(CC3CC3)C(=O)N3CCC4C3C(=O)CN4C(=O)Cc3cccnc3)cc2c1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.48
CHRNA7 P36544 3/20 0.48
CHRNA4 P43681 3/20 0.48
ALDH1A1 P00352 1/20 0.43
HPGD P15428 1/20 0.43
TAS1R3 Q7RTX0 11/20 0.42
TAS1R1 Q7RTX1 11/20 0.42
CTSK P43235 3/20 0.40
CTSL P07711 2/20 0.40
CTSS P25774 2/20 0.40
CTSB P07858 1/20 0.39
HTRA1 Q92743 1/20 0.38
HTR1A P08908 1/20 0.37
DRD2 P14416 1/20 0.37
HTR2A P28223 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4043880 0.91 CHRNB2 (0.41) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4047073 0.83 CHRNB2 (0.43) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4044034 0.83 CHRNB2 (0.41) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4044847 0.82 CHRNB2 (0.39) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4046951 0.81 CTSK (0.47) CTSKCTSLCTSSHTRA1
SCHEMBL4049108 0.79 CTSK (0.57) ALDH1A1HPGDCTSKCTSLCTSS
SCHEMBL4046945 0.79 CTSK (0.55) CHRNB2CHRNA7CHRNA4ALDH1A1CTSK
SCHEMBL6212161 0.79 CTSK (0.41) TAS1R3TAS1R1CTSKCTSLCTSS
SCHEMBL4049417 0.79 CHRNB2 (0.40) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4039388 0.79 CTSK (0.45) CHRNB2CHRNA7CHRNA4CTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1546150-A1 BIOLOGICALLY ACTIVE COMPOUNDS Amura Therapeutics Limited (GB) 2005-06-29 EP disclosed
WO-2004007501-A1 BIOLOGICALLY ACTIVE COMPOUNDS AMURA THERAPEUTICS LIMITED (GB) 2004-01-22 WO disclosed