SCHEMBL4043880

SCHEMBL4043880

COc1ccc2oc(OC(=O)NC(CC3CC3)C(=O)N3CCC4C3C(=O)CN4C(=O)Cc3cccnc3)cc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.41
CHRNA7 P36544 1/20 0.41
CHRNA4 P43681 1/20 0.41
ALDH1A1 P00352 3/20 0.40
HPGD P15428 1/20 0.40
IDO1 P14902 1/20 0.36
HTRA1 Q92743 1/20 0.34
KDM4E B2RXH2 1/20 0.33
GAA P10253 1/20 0.33
PTAFR P25105 3/20 0.32
KMT2A Q03164 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
TAS1R3 Q7RTX0 2/20 0.32
TAS1R1 Q7RTX1 2/20 0.32
PAX8 Q06710 1/20 0.32
CTSK P43235 1/20 0.32
CXCR3 P49682 1/20 0.32
MTNR1A P48039 1/20 0.32
MTNR1B P49286 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4047073 0.93 CHRNB2 (0.43) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4044034 0.93 CHRNB2 (0.41) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL6237885 0.91 CHRNB2 (0.48) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4044847 0.90 CHRNB2 (0.39) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4049417 0.88 CHRNB2 (0.40) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4043537 0.86 PIK3CG (0.37) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4043842 0.85 CHRNB2 (0.36) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4042383 0.84 CTSK (0.42) CHRNB2CHRNA7CHRNA4CTSK
SCHEMBL4039519 0.84 CTSK (0.37) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4046786 0.84 CHRNB2 (0.36) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506175-B1 N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2009-04-01 EP disclosed