SCHEMBL4044847

SCHEMBL4044847

COc1ccc2oc(OC(=O)NC(Cc3cccs3)C(=O)N3CCC4C3C(=O)CN4C(=O)Cc3cccnc3)cc2c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.39
CHRNA7 P36544 1/20 0.39
CHRNA4 P43681 1/20 0.39
ALDH1A1 P00352 3/20 0.38
HPGD P15428 1/20 0.38
IDO1 P14902 1/20 0.34
TRPM8 Q7Z2W7 2/20 0.33
F12 P00748 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
TAS1R3 Q7RTX0 2/20 0.32
TAS1R1 Q7RTX1 2/20 0.32
KDM4E B2RXH2 1/20 0.32
GAA P10253 1/20 0.32
CTSK P43235 4/20 0.32
CTSL P07711 1/20 0.31
CTSB P07858 1/20 0.31
CTSS P25774 1/20 0.31
HTT P42858 1/20 0.31
PTAFR P25105 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4047073 0.90 CHRNB2 (0.43) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4043880 0.90 CHRNB2 (0.41) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4044034 0.90 CHRNB2 (0.41) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4046322 0.89 CHRNB2 (0.38) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4043432 0.87 KCNQ1 (0.38) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4045350 0.86 CHRNB2 (0.34) CHRNB2CHRNA7CHRNA4ALDH1A1HPGD
SCHEMBL4043865 0.85 CTSK (0.36) ALDH1A1HPGDTRPM8TAS1R3TAS1R1
SCHEMBL4042383 0.82 CTSK (0.42) CHRNB2CHRNA7CHRNA4CTSKCTSL
SCHEMBL4044961 0.82 CHRNB2 (0.35) CHRNB2CHRNA7CHRNA4F12GAA
SCHEMBL4049501 0.82 CTSK (0.40) HPGDTRPM8CTSKCTSLCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1546150-B1 PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES AMURA THERAPEUTICS LTD (GB) 2009-03-04 EP claimed