Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 15/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 13/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 4/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
| ▸ | BID | P55957 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237169 | 0.87 | ADAM17 (0.58) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL6233609 | 0.87 | ADAM17 (0.58) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL6240112 | 0.86 | MMP1 (0.50) | MMP1ADAM17S1PR1S1PR5MMP13 | |
| SCHEMBL6240908 | 0.86 | MMP1 (0.49) | MMP1ADAM17S1PR1S1PR5MMP13 | |
| SCHEMBL6240990 | 0.84 | MMP1 (0.57) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL6238194 | 0.77 | MMP1 (0.55) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL6240212 | 0.76 | MMP1 (0.51) | MMP1ADAM17MMP13ADAMTS4MMP3 | |
| SCHEMBL6237935 | 0.76 | MMP1 (0.52) | MMP1ADAM17MMP13ADAMTS4MMP3 | |
| SCHEMBL6238727 | 0.76 | MMP1 (0.54) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL6238179 | 0.76 | MMP1 (0.54) | MMP1ADAM17MMP13MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104412-B1 | TACE INHIBITORS | PFIZER PROD INC (US) | 2005-06-15 | — | — | EP | claimed |