Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 6/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4820884 | 0.85 | TRPM5 (0.55) | KDM4ESMN1; SMN2KMT2ARAB9AHPGD | |
| SCHEMBL6241356 | 0.84 | KDM4E (0.48) | KDM4ESMN1; SMN2KMT2ARAB9AMGAM | |
| Oxindole SCHEMBL27946247 | 0.83 | AHR (0.44) | KDM4ESMN1; SMN2KMT2ARAB9ANPC1 | |
| SCHEMBL3930818 | 0.83 | MAP4K4 (0.57) | KDM4ESMN1; SMN2KMT2ARAB9ANPC1 | |
| SCHEMBL20346355 | 0.81 | ALDH1A1 (0.59) | KDM4ESMN1; SMN2KMT2ARAB9AMGAM | |
| SCHEMBL11683110 | 0.81 | KDM4E (0.48) | KDM4ESMN1; SMN2KMT2ARAB9ANPC1 | |
| SCHEMBL3102896 | 0.81 | MGAM (0.57) | KDM4ESMN1; SMN2KMT2ARAB9ARPS6KB2 | |
| SCHEMBL29750532 | 0.81 | MGAM (0.57) | KDM4ESMN1; SMN2KMT2ARAB9ARPS6KB2 | |
| SCHEMBL359850 | 0.81 | ALOX15 (0.58) | KDM4ESMN1; SMN2KMT2ARAB9ANPC1 | |
| SCHEMBL22255880 | 0.80 | KMT2A (0.47) | KDM4ESMN1; SMN2KMT2ARAB9AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019177-A1 | AMINOPIPERIDINE AMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| WO-2005019177-A1 | AMINOPIPERIDINE AMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |