Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 7/20 | 0.41 |
| ▸ | CDK4 | P11802 | 7/20 | 0.41 |
| ▸ | CCND1 | P24385 | 7/20 | 0.41 |
| ▸ | CDK2 | P24941 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CASK | O14936 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | CDK14 | O94921 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1946301 | 0.86 | FYN (0.54) | FYNF2RL3SSTR5MAPTNPC1 | |
| SCHEMBL1945924 | 0.85 | FYN (0.66) | FYNF2RL3SSTR5MAPTNPC1 | |
| SCHEMBL2255826 | 0.84 | FYN (0.52) | FYNF2RL3SSTR5MAPTNPC1 | |
| SCHEMBL624431 | 0.83 | FYN (0.48) | FYNF2RL3CDK1CDK4CCND1 | |
| SCHEMBL623927 | 0.81 | FYN (0.72) | FYN | |
| SCHEMBL626172 | 0.80 | DYRK1A (0.38) | FYNCDK1CDK4CCND1CDK2 | |
| SCHEMBL626187 | 0.77 | JAK3 (0.38) | FYNF2RL3CDK1CDK4CCND1 | |
| SCHEMBL626165 | 0.77 | IDO1 (0.47) | F2RL3CDK1CDK4CCND1CDK2 | |
| SCHEMBL1946744 | 0.77 | FYN (0.56) | FYNF2RL3MAPTNPC1RAB9A | |
| SCHEMBL627168 | 0.76 | CCNE1 (0.39) | CDK1CDK4CCND1CDK2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |