Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.38 |
| ▸ | CDK1 | P06493 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626172 | 0.88 | DYRK1A (0.38) | FYNDYRK1ACDK1CDK2CCNB2 | |
| SCHEMBL625477 | 0.87 | FYN (0.50) | FYNPIK3R1PIK3CACA12CA1 | |
| SCHEMBL1944169 | 0.86 | FYN (0.53) | FYNSYKCA12CA1CA2 | |
| SCHEMBL626165 | 0.85 | IDO1 (0.47) | F2RL3CDK1CDK2CCNB2CCNE2 | |
| SCHEMBL626187 | 0.85 | JAK3 (0.38) | FYNDYRK1AJAK3F2RL3CDK1 | |
| SCHEMBL625465 | 0.84 | FYN (0.52) | FYNDYRK1ASYKCA12CA1 | |
| SCHEMBL2253571 | 0.84 | FYN (0.52) | FYNSYKBRAFPDE4APDE4B | |
| SCHEMBL623928 | 0.83 | FYN (0.49) | FYNDYRK1APDE4BF2RL3CDK1 | |
| SCHEMBL624430 | 0.82 | FYN (0.72) | FYNPIK3CA | |
| SCHEMBL626207 | 0.78 | MAP3K12 (0.46) | PIK3CACDK1CDK2CCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |