Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25985295 | 0.96 | TSHR (0.47) | TSHRSMN1; SMN2HTTHTR1AADRA1D | |
| SCHEMBL21207996 | 0.93 | TSHR (0.44) | TSHRSMN1; SMN2HTTHTR1AADRA1D | |
| SCHEMBL8760726 | 0.90 | TSHR (0.61) | TSHRSMN1; SMN2HTTHTR1AADRA1D | |
| SCHEMBL11935005 | 0.90 | SIGMAR1 (0.49) | TSHRSIGMAR1 | |
| SCHEMBL7134228 | 0.88 | TSHR (0.58) | TSHRSMN1; SMN2HTTHTR1AADRA1D | |
| SCHEMBL1923484 | 0.86 | DRD2 (0.47) | TSHRHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL8160604 | 0.86 | TSHR (0.47) | TSHRSMN1; SMN2HTTHTR1AADRA1D | |
| SCHEMBL31474275 | 0.85 | TSHR (0.50) | TSHRSMN1; SMN2HTTHTR1AADRA1D | |
| SCHEMBL8154723 | 0.84 | TSHR (0.45) | TSHRSMN1; SMN2HTTHTR1AADRA1D | |
| SCHEMBL6237709 | 0.82 | DRD2 (0.47) | HTR1AADRA1DADRA1AADRA1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005011697-A2 | SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-10 | — | — | WO | claimed |
| WO-2005011697-A2 | SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |