Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.50 |
| ▸ | RARG | P13631 | 5/20 | 0.50 |
| ▸ | RARB | P10826 | 4/20 | 0.50 |
| ▸ | HNF4A | P41235 | 2/20 | 0.48 |
| ▸ | CDC25B | P30305 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RARA | P10276 | 3/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.45 |
| ▸ | RXRG | P48443 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236924 | 0.88 | CDC25B (0.59) | RXRARARGRARBHNF4ACDC25B | |
| SCHEMBL6239480 | 0.83 | RARG (0.49) | RXRARARGRARBRARARXRB | |
| SCHEMBL6242642 | 0.82 | HNF4A (0.68) | RXRARARGRARBHNF4ACDC25B | |
| SCHEMBL6241850 | 0.82 | RXRA (0.55) | RXRARARGRARBHNF4ACDC25B | |
| SCHEMBL6244136 | 0.80 | RXRA (0.62) | RXRARARGRARBCDC25BATM | |
| SCHEMBL6243030 | 0.79 | RXRA (0.55) | RXRARARGRARBHNF4ACDC25B | |
| SCHEMBL6242986 | 0.78 | RXRA (0.50) | RXRARARGRARBHNF4ACDC25B | |
| SCHEMBL6242094 | 0.78 | HNF4A (0.57) | RXRARARGRARBHNF4ACDC25B | |
| SCHEMBL6242478 | 0.78 | HNF4A (0.54) | RXRARARGRARBHNF4ACDC25B | |
| SCHEMBL6239175 | 0.75 | RXRA (0.67) | RXRARARGRARBHNF4ACDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |