Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13959322 | 0.81 | GSK3B (0.36) | HTTMMP2KMT2AMEN1NPC1 | |
| SCHEMBL13716194 | 0.81 | GSK3B (0.41) | HTTMMP2KMT2AMEN1NPC1 | |
| SCHEMBL6238882 | 0.79 | OGG1 (0.41) | MMP2KMT2AMEN1MAPTMMP13 | |
| SCHEMBL5724902 | 0.79 | PTGIR (0.38) | HTTMAPT | |
| SCHEMBL6241857 | 0.79 | KEAP1 (0.42) | HTTKMT2AMEN1NPC1KDM4E | |
| SCHEMBL13716114 | 0.76 | GSK3B (0.35) | HTTMMP2KMT2AMEN1NPC1 | |
| SCHEMBL29624301 | 0.76 | PARP15 (0.46) | HTTMMP2KMT2AMEN1NPC1 | |
| SCHEMBL22251861 | 0.75 | IDO1 (0.43) | HTTMMP2KMT2AMEN1GSK3B | |
| SCHEMBL28980379 | 0.74 | NOS3 (0.46) | MMP2GSK3BCA1CA2MAPT | |
| SCHEMBL14141146 | 0.73 | KMT2A (0.39) | HTTMMP2KMT2AGSK3BCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005002574-A1 | PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PLATELET AGGREGATION INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-01-13 | — | — | WO | disclosed |