Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ACSL1 | P33121 | 3/20 | 0.49 |
| ▸ | ACSL6 | Q9UKU0 | 3/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430903 | 0.91 | LMNA (0.53) | LMNAMAPTNPC1RAB9APOLB | |
| SCHEMBL9413588 | 0.89 | NPC1 (0.68) | LMNAMAPTNPC1RAB9APOLB | |
| SCHEMBL20322895 | 0.89 | LMNA (0.60) | LMNAMAPTNPC1RAB9APOLB | |
| SCHEMBL6828889 | 0.83 | LMNA (0.60) | LMNAMAPTNPC1RAB9APTGER4 | |
| SCHEMBL9131367 | 0.81 | LMNA (0.56) | LMNAMAPTNPC1PTGER4MAOA | |
| SCHEMBL20322862 | 0.80 | LMNA (1.00) | LMNAMAPTNPC1RAB9APOLB | |
| SCHEMBL14541242 | 0.79 | CA12 (0.58) | LMNAMAPTNPC1RAB9APOLB | |
| SCHEMBL25524814 | 0.78 | MAOA (0.68) | MAPTNPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL2343267 | 0.78 | MAPT (0.47) | LMNAMAPTNPC1RAB9APOLB | |
| SCHEMBL17902702 | 0.78 | MAPT (0.59) | LMNAMAPTNPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320523-B1 | BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | claimed |