Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.47 |
| ▸ | THRB | P10828 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11005416 | 0.76 | RXFP1 (0.61) | LMNATP53RXFP1THRBMAPT | |
| SCHEMBL23725824 | 0.76 | HASPIN (0.41) | LMNATP53RXFP1THRB | |
| SCHEMBL23268398 | 0.75 | HASPIN (0.39) | — | |
| SCHEMBL627087 | 0.74 | HASPIN (0.42) | LMNATHRB | |
| SCHEMBL23268407 | 0.72 | HASPIN (0.47) | LMNATP53RXFP1THRB | |
| SCHEMBL627054 | 0.72 | KDM4E (0.48) | LMNATP53RXFP1THRBMAPT | |
| SCHEMBL627772 | 0.72 | HRH3 (0.41) | LMNATP53RXFP1THRBPOLB | |
| SCHEMBL627209 | 0.72 | HASPIN (0.40) | LMNATP53RXFP1THRB | |
| SCHEMBL625796 | 0.72 | PIK3CA (0.47) | LMNATP53RXFP1THRBMAPT | |
| SCHEMBL23288616 | 0.71 | KCNH2 (0.45) | LMNATP53RXFP1THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |