Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TMPRSS15 | P98073 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627222 | 0.83 | LMNA (0.39) | LMNATHRBTP53RXFP1 | |
| SCHEMBL627999 | 0.81 | LMNA (0.41) | LMNATHRBTP53MAPTL3MBTL1 | |
| SCHEMBL23268299 | 0.78 | LMNA (0.39) | LMNATHRBTP53RXFP1POLB | |
| SCHEMBL625663 | 0.78 | FYN (0.56) | KDM4ELMNATHRBMAPT | |
| SCHEMBL627055 | 0.76 | MAPT (0.48) | KDM4ELMNATHRBMEN1KMT2A | |
| SCHEMBL626886 | 0.76 | CKS1B (0.50) | LMNATP53 | |
| SCHEMBL23288616 | 0.75 | KCNH2 (0.45) | LMNATHRBTP53MAPTL3MBTL1 | |
| SCHEMBL625746 | 0.74 | PIK3CA (0.54) | TMPRSS15 | |
| SCHEMBL627264 | 0.73 | CKS1B (0.43) | LMNATHRBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25407503 | 0.73 | TMPRSS15 (0.61) | KDM4ETMPRSS15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |