Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 8/20 | 0.38 |
| ▸ | JAK2 | O60674 | 7/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | TXK | P42681 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623829 | 0.87 | F2RL3 (0.48) | JAK2GPR119SCD5SCN9A | |
| SCHEMBL625496 | 0.86 | PIM1 (0.39) | HSD17B10IRAK4SCD5 | |
| SCHEMBL624036 | 0.85 | FYN (0.46) | CYP2D6HSD17B10IRAK4GPR119 | |
| SCHEMBL624979 | 0.82 | ADORA2A (0.38) | HSD17B10ADORA2AROCK2 | |
| SCHEMBL626983 | 0.82 | CETP (0.44) | HSD17B10ADORA2AJAK1JAK2GPR119 | |
| SCHEMBL625492 | 0.79 | NAMPT (0.39) | GPR119 | |
| SCHEMBL625408 | 0.79 | MAP4K1 (0.39) | — | |
| SCHEMBL623873 | 0.75 | IDH1 (0.44) | HSD17B10GPR119 | |
| SCHEMBL624454 | 0.75 | PIM1 (0.45) | GPR119 | |
| SCHEMBL625243 | 0.73 | FYN (0.60) | JAK2SCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |