Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 4/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624058 | 0.87 | JAK2 (0.47) | PRMT5KDM4EMAPTJAK2PKM | |
| SCHEMBL628029 | 0.87 | F2RL3 (0.49) | PRMT5KDM4EMAPTPKMGPR119 | |
| SCHEMBL624533 | 0.85 | PIM1 (0.53) | PRMT5KDM4EMAPTPKMKDM1A | |
| SCHEMBL626982 | 0.84 | FYN (0.56) | CETPPRMT5KDM4EPKMGPR119 | |
| SCHEMBL624037 | 0.82 | CYP2D6 (0.39) | JAK2GPR119ADORA2AHSD17B10JAK1 | |
| SCHEMBL623852 | 0.82 | FYN (0.42) | ADORA2AHSD17B10 | |
| SCHEMBL626460 | 0.79 | MAPT (0.46) | PRMT5KDM4EMAPTGPR119HPGD | |
| SCHEMBL27614055 | 0.79 | TGFBR1 (0.54) | CETPKDM4EPKMGPR119NOTCH1 | |
| SCHEMBL627067 | 0.78 | KDM4E (0.46) | PRMT5KDM4EMAPTJAK2PKM | |
| SCHEMBL624985 | 0.78 | KDM4E (0.40) | PRMT5KDM4EMAPTGPR119HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |