Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.68 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.68 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.68 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.68 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.68 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.68 |
| ▸ | SNCA | P37840 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6242249 | 0.78 | HDAC1 (0.52) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL6942450 | 0.75 | SNCA (0.54) | SNCAKEAP1NFE2L2SQSTM1LMNA | |
| SCHEMBL6942459 | 0.75 | SNCA (0.54) | SNCAKEAP1NFE2L2SQSTM1LMNA | |
| SCHEMBL12768028 | 0.74 | KEAP1 (0.81) | SNCAKEAP1NFE2L2SQSTM1LMNA | |
| SCHEMBL6239619 | 0.73 | KMT2A (0.55) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL6949416 | 0.72 | CCR9 (0.52) | SNCAKEAP1NFE2L2SQSTM1LMNA | |
| SCHEMBL6949415 | 0.72 | CCR9 (0.52) | SNCAKEAP1NFE2L2SQSTM1LMNA | |
| SCHEMBL8626209 | 0.72 | LMNA (0.72) | KEAP1NFE2L2SQSTM1LMNAHPGD | |
| SCHEMBL1403255 | 0.72 | HDAC8 (0.64) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL26042896 | 0.71 | SNCA (0.74) | HDAC1SNCAKEAP1NFE2L2SQSTM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005011661-A1 | PHARMACEUTICAL AGENTS | UNIVERSITY COLLEGE LONDON (GB) | 2005-02-10 | — | — | WO | disclosed |