Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenbutyramide SCHEMBL1477997 | 0.73 | EPHX1 (0.63) | EPHX1LMNAHSD17B10 | |
| Fenbutyramide SCHEMBL232920 | 0.73 | EPHX1 (0.63) | EPHX1LMNAHSD17B10 | |
| Fenbutyramide SCHEMBL1478462 | 0.73 | EPHX1 (0.63) | EPHX1LMNAHSD17B10 | |
| SCHEMBL26898446 | 0.72 | ALDH1A1 (0.50) | ALOX5EPHX1CYP3A4MMP9MMP8 | |
| SCHEMBL4943215 | 0.72 | LMNA (0.54) | EPHX1CYP3A4MMP9MMP8MMP13 | |
| SCHEMBL2290009 | 0.72 | EPHX1 (0.43) | EPHX1CYP3A4MMP9MMP8MMP13 | |
| SCHEMBL28234925 | 0.72 | CRHBP (0.53) | EPHX1MMP9MMP8MMP13LMNA | |
| Hydrochloric Acid SCHEMBL4373252 | 0.72 | ALOX5 (0.50) | ALOX5TRPA1CYP3A4SLC1A3SLC1A2 | |
| Fenbutyramide SCHEMBL15995561 | 0.72 | EPHX1 (0.61) | EPHX1LMNAHSD17B10 | |
| SCHEMBL2244613 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077928-B1 | NOVEL SUBSTITUTED CYCLIC COMPOUNDS, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2005-12-07 | — | — | EP | disclosed |
| EP-1077927-B1 | NOVEL SUBSTITUTED CYCLIC COMPOUNDS, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2005-12-07 | — | — | EP | disclosed |
| CN-1300277-A | Novel substituted cyclic compounds, preparation method and pharmaceutical compositions containing them | ADIR (FR) | 2001-06-20 | — | — | CN | disclosed |