Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | SLC9A5 | Q14940 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28323735 | 0.74 | LMNA (0.56) | MAPTCYP1A2CYP2C19CYP2C9NUDT1 | |
| SCHEMBL17822435 | 0.72 | CTSK (0.52) | MAPTCYP1A2CYP2C19CYP2C9NUDT1 | |
| SCHEMBL17822445 | 0.70 | LMNA (0.55) | LMNACTSKHSD17B10ALDH1A1TSHR | |
| SCHEMBL17822430 | 0.70 | LMNA (0.55) | LMNACTSKHSD17B10ALDH1A1TSHR | |
| SCHEMBL9663929 | 0.69 | LMNA (0.50) | MAPTCYP1A2CYP2C19CYP2C9NUDT1 | |
| SCHEMBL12457406 | 0.69 | ALDH1A1 (0.44) | MAPTCYP1A2CYP2C19CYP2C9NUDT1 | |
| Hydrochloric Acid SCHEMBL17822431 | 0.68 | LMNA (0.53) | LMNACTSKHSD17B10ALDH1A1TSHR | |
| SCHEMBL5774307 | 0.68 | MEN1 (0.47) | LMNACTSKHSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6250270 | 0.68 | LMNA (0.49) | MAPTCYP1A2CYP2C19CYP2C9NUDT1 | |
| SCHEMBL27741341 | 0.68 | HSD17B10 (0.44) | MAPTCYP1A2CYP2C19CYP2C9NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546129-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS ANTITUMOR AGENT | Pharmacia Italia S.p.A. (IT) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004024711-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS ANTITUMOR AGENT | PHARMACIA ITALIA S.P.A. (IT) | 2004-03-25 | — | — | WO | disclosed |