Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624589 | 0.89 | TRPV3 (0.46) | TRPV3OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL625379 | 0.89 | TRPV3 (0.52) | TRPV3OPRK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14894505 | 0.86 | TRPV3 (0.44) | TRPV3OPRL1OPRM1SLC6A2SLC6A4 | |
| SCHEMBL625715 | 0.86 | TRPV3 (0.46) | TRPV3OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL626128 | 0.86 | TRPV3 (0.52) | TRPV3OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL625341 | 0.83 | TRPV3 (0.72) | TRPV3SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL625907 | 0.80 | NR1I2 (0.46) | TRPV3SLC6A2NR1I2 | |
| SCHEMBL14956815 | 0.72 | TRPV3 (0.66) | TRPV3OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL14894515 | 0.72 | TRPV3 (0.62) | TRPV3OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL625811 | 0.72 | TRPV3 (0.65) | TRPV3OPRL1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |