Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625379 | 0.86 | TRPV3 (0.52) | TRPV3SLC6A4SLC6A3SLC6A2OPRK1 | |
| SCHEMBL624609 | 0.86 | TRPV3 (0.47) | TRPV3SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL625715 | 0.85 | TRPV3 (0.46) | TRPV3SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL625341 | 0.85 | TRPV3 (0.72) | TRPV3SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL625907 | 0.80 | NR1I2 (0.46) | TRPV3SLC6A2 | |
| SCHEMBL624589 | 0.79 | TRPV3 (0.46) | TRPV3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL626127 | 0.76 | TRPV3 (0.46) | TRPV3SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL14894505 | 0.76 | TRPV3 (0.44) | TRPV3SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL27925696 | 0.73 | SLC6A4 (0.43) | TRPV3SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL14893768 | 0.72 | TRPV3 (0.54) | TRPV3SLC6A4SLC6A3SLC6A2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | claimed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | claimed |
| EP-2771322-A2 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2014-09-03 | — | — | EP | disclosed |
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2013062966-A2 | NOVEL TRPV3 MODULATORS | ABBVIE INC. (US) | 2013-05-02 | — | — | WO | disclosed |
| WO-2013062964-A2 | NOVEL TRPV3 MODULATORS | ABBVIE INC. (US) | 2013-05-02 | — | — | WO | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |