Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625379 | 0.86 | TRPV3 (0.52) | TRPV3SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL626128 | 0.85 | TRPV3 (0.52) | TRPV3SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL625562 | 0.84 | TRPV3 (1.00) | TRPV3SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL625563 | 0.84 | TRPV3 (1.00) | TRPV3SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL624609 | 0.83 | TRPV3 (0.47) | TRPV3SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL624589 | 0.81 | TRPV3 (0.46) | TRPV3KCNH2 | |
| SCHEMBL10561584 | 0.81 | TRPV3 (0.73) | TRPV3SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL625715 | 0.81 | TRPV3 (0.46) | TRPV3SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL624943 | 0.80 | TRPV3 (0.93) | TRPV3SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL14893522 | 0.78 | TRPV3 (0.90) | TRPV3SLC6A4SLC6A3SLC6A2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | claimed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | claimed |
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2013062966-A2 | NOVEL TRPV3 MODULATORS | ABBVIE INC. (US) | 2013-05-02 | — | — | WO | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |