Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.52 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624609 | 0.89 | TRPV3 (0.47) | TRPV3TSHRSLC6A4SLC6A3CHRM2 | |
| SCHEMBL624589 | 0.87 | TRPV3 (0.46) | TRPV3KCNH2OPRK1ALDH1A1NR1I2 | |
| SCHEMBL626128 | 0.86 | TRPV3 (0.52) | TRPV3CCR1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL625341 | 0.86 | TRPV3 (0.72) | TRPV3SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL14894505 | 0.84 | TRPV3 (0.44) | TRPV3SLC6A4SLC6A3SLC6A2MAPT | |
| SCHEMBL10562244 | 0.80 | TRPV3 (0.52) | TRPV3CCR1TSHRCYP3A4ALOX15 | |
| SCHEMBL625715 | 0.79 | TRPV3 (0.46) | TRPV3TSHRCYP3A4SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL10559936 | 0.78 | TRPV3 (0.51) | TRPV3CCR1TSHRCYP3A4ALOX15 | |
| SCHEMBL625378 | 0.74 | TRPV3 (0.49) | TRPV3CCR1TSHRSLC6A4SLC6A3 | |
| SCHEMBL625907 | 0.73 | NR1I2 (0.46) | TRPV3SLC6A2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2013062966-A2 | NOVEL TRPV3 MODULATORS | ABBVIE INC. (US) | 2013-05-02 | — | — | WO | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |