Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.69 |
| ▸ | DRD3 | P35462 | 2/20 | 0.66 |
| ▸ | HTR1A | P08908 | 5/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL948083 | 0.92 | DRD2 (0.71) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL30080790 | 0.92 | DRD2 (0.71) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL6954563 | 0.91 | HTR1A (0.71) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL8131969 | 0.86 | DRD2 (0.69) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL5813483 | 0.85 | ADRA1A (0.67) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL4530500 | 0.84 | MAPT (0.51) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL6526368 | 0.83 | DRD2 (0.85) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL31060769 | 0.82 | DRD2 (1.00) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL3261221 | 0.82 | DRD2 (1.00) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL8363314 | 0.82 | DRD2 (0.77) | DRD2DRD3HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114163402-B | Industrial preparation method of 3- [4- (2-methoxyphenyl) piperazine-1-yl ] propionitrile | 河北一品生物医药有限公司 | 2023-08-04 | — | — | CN | claimed |
| CN-114163402-A | Industrial preparation method of 3- [4- (2-methoxyphenyl) piperazine-1-yl ] propionitrile | 河北一品生物医药有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-114163402-B | Industrial preparation method of 3- [4- (2-methoxyphenyl) piperazine-1-yl ] propionitrile | 河北一品生物医药有限公司 | 2023-08-04 | — | — | CN | disclosed |
| CN-114163402-B | Industrial preparation method of 3- [4- (2-methoxyphenyl) piperazine-1-yl ] propionitrile | 河北一品生物医药有限公司 | 2023-08-04 | — | — | CN | disclosed |
| CN-114163402-B | Industrial preparation method of 3- [4- (2-methoxyphenyl) piperazine-1-yl ] propionitrile | 河北一品生物医药有限公司 | 2023-08-04 | — | — | CN | disclosed |
| CN-114163402-A | Industrial preparation method of 3- [4- (2-methoxyphenyl) piperazine-1-yl ] propionitrile | 河北一品生物医药有限公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-114163402-A | Industrial preparation method of 3- [4- (2-methoxyphenyl) piperazine-1-yl ] propionitrile | 河北一品生物医药有限公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-114163402-A | Industrial preparation method of 3- [4- (2-methoxyphenyl) piperazine-1-yl ] propionitrile | 河北一品生物医药有限公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2005037281-A1 | 1-ALKYLPIPERAZINYL-PYRROLIDIN-2, 5-DIONE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONIST | RANBAXY LABORATORIES LIMITED (IN) | 2005-04-28 | — | — | WO | disclosed |
| CN-1084619-C | Process for preparing medicine composition | WYETH JOHN & BROTHER LTD (GB) | 2002-05-15 | — | — | CN | disclosed |
| US-6127357-A | N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides | JOHN WYETH & BROTHER, LTD. (GB) | 2000-10-03 | — | — | US | disclosed |
| CN-1206589-A | Process for preparing medicine composition | WYETH JOHN & BROTHER LTD (GB) | 1999-02-03 | — | — | CN | disclosed |
| EP-0512755-B1 | Piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1994-12-14 | — | — | EP | disclosed |
| EP-0512755-A2 | Piperazine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |
| EP-0395313-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-31 | — | — | EP | disclosed |