Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104093 | 0.85 | KMT2A (0.49) | KMT2AMAPTMEN1MAPK8LMNA | |
| SCHEMBL7088107 | 0.76 | ROCK2 (0.58) | KMT2AMAPTMEN1LMNAL3MBTL1 | |
| SCHEMBL8094492 | 0.70 | MAPK8 (0.41) | MAPK8ALDH1A1HTTGAA | |
| SCHEMBL4290852 | 0.69 | ALDH1A1 (0.44) | KMT2AMAPTMEN1LMNAL3MBTL1 | |
| SCHEMBL27874614 | 0.68 | ALDH1A1 (0.55) | KMT2AMAPTMEN1LMNAALDH1A1 | |
| SCHEMBL5657581 | 0.67 | MEN1 (0.70) | KMT2AMAPTMEN1LMNAL3MBTL1 | |
| SCHEMBL8988041 | 0.67 | POLB (0.57) | KMT2AMAPTMEN1LMNAL3MBTL1 | |
| SCHEMBL6246258 | 0.67 | SRD5A2 (0.58) | KMT2AMAPTMEN1ALDH1A1RAB9A | |
| SCHEMBL18177310 | 0.66 | MAPT (0.61) | KMT2AMAPTMEN1MAPK8LMNA | |
| SCHEMBL31564998 | 0.65 | MAPT (0.54) | KMT2AMAPTMEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040143-A1 | 5-(2-ARYLACETAMIDO)ISOTHIAZOLE COMPOUNDS II | BASF AKTIENGESELLSCHAFT (DE) | 2005-05-06 | — | — | WO | disclosed |