Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | CDK4 | P11802 | 4/20 | 0.37 |
| ▸ | CCND1 | P24385 | 4/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995369 | 0.85 | CDK4 (0.42) | ALDH1A1HTTHPGDRAB9ACDK4 | |
| SCHEMBL321199 | 0.72 | CDK4 (0.45) | ALDH1A1HTTHPGDRAB9ACDK4 | |
| SCHEMBL29614841 | 0.72 | CDK4 (0.45) | ALDH1A1HTTHPGDRAB9ACDK4 | |
| SCHEMBL9044989 | 0.72 | VDR (0.51) | ALDH1A1HTTKDM4EHPGDTDP1 | |
| SCHEMBL17913218 | 0.71 | MGLL (0.44) | CDK4CCND1SLC6A2TDP1MAPT | |
| Hydrochloric Acid SCHEMBL7218572 | 0.71 | CDK4 (0.43) | ALDH1A1HTTHPGDRAB9ACDK4 | |
| SCHEMBL3576716 | 0.69 | CDK4 (0.47) | ALDH1A1KDM4ECDK4CCND1NOTUM | |
| SCHEMBL10932323 | 0.69 | CDK4 (0.42) | ALDH1A1HTTHPGDRAB9ACDK4 | |
| SCHEMBL30233726 | 0.69 | CDK4 (0.47) | ALDH1A1KDM4ECDK4CCND1NOTUM | |
| SCHEMBL4287685 | 0.69 | CDC7 (0.39) | ALDH1A1CDK4CCND1NOTUMSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411942-A4 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1411942-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | Synaptic Pharmaceutical Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003004027-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2003-01-16 | — | — | WO | disclosed |