Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8368446 | 0.75 | VDR (0.58) | VDRALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL9037283 | 0.73 | CYP24A1 (0.53) | ALDH1A1HPGDMEN1KMT2AUSP2 | |
| SCHEMBL29414854 | 0.73 | HTR6 (0.75) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL1673252 | 0.73 | HTR6 (0.75) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL6247012 | 0.72 | ALDH1A1 (0.41) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL1203289 | 0.72 | HTR6 (0.73) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL10395507 | 0.72 | VDR (0.57) | VDRALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL8122231 | 0.72 | CYP24A1 (0.62) | ALDH1A1MEN1KMT2AUSP2ESR1 | |
| SCHEMBL9056488 | 0.71 | HTT (0.43) | VDRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9056479 | 0.71 | SLC6A2 (0.38) | VDRALDH1A1HPGDKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445781-B1 | 3-Arylcarbonyl-1-aminoalkyl-1H-indole containing antiglaucoma compositions | STERLING WINTHROP INC (US) | 1996-01-31 | — | — | EP | disclosed |
| EP-0445781-A1 | 3-Arylcarbonyl-1-aminoalkyl-1H-indole containing antiglaucoma compositions | STERLING WINTHROP INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-5013837-A | Treatment of glaucoma | STERLING DRUG INC. (US) | 1991-05-07 | — | — | US | disclosed |
| US-4973587-A | 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method | STERLING DRUG INC. (US) | 1990-11-27 | — | — | US | disclosed |