Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6249708 | 0.83 | CXCR3 (0.40) | MMP2ADAMTS5CYP19A1CXCR3MMP13 | |
| SCHEMBL6139175 | 0.83 | CYP19A1 (0.45) | CYP19A1 | |
| SCHEMBL7505925 | 0.83 | CYP19A1 (0.45) | CYP19A1 | |
| Hydrochloric Acid SCHEMBL7505934 | 0.82 | CYP19A1 (0.44) | CYP19A1 | |
| SCHEMBL7749347 | 0.76 | CYP19A1 (0.43) | CYP19A1SLC6A4SLC6A3CXCR3 | |
| SCHEMBL7749405 | 0.67 | CYP19A1 (0.45) | CYP19A1 | |
| SCHEMBL6248121 | 0.65 | SLC6A4 (0.38) | CYP19A1SLC6A2SLC6A4SLC6A3CXCR3 | |
| SCHEMBL7750542 | 0.65 | SLC6A4 (0.40) | L3MBTL1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11847657 | 0.65 | ALDH1A1 (0.54) | CYP19A1 | |
| SCHEMBL14282291 | 0.65 | DRD2 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140841-B1 | 3-PHENYL-2,6-DIOXOPIPERIDIN-3-YL PROPIONAMIDE DERIVATIVES AND METHOD FOR PREPARING SAME | SANOFI AVENTIS (FR) | 2005-08-17 | — | — | EP | disclosed |
| US-6452012-B1 | USEFULL CHEMICAL INTERMEDIATES FOR SYNTHESIS OF NEUROKININ ANTAGONISTS | SANOFI-SYNTHELABO (FR) | 2002-09-17 | — | — | US | disclosed |
| US-6342607-B1 | INTERMEDIATES FOR PREPARATION OF NEUROKININ ANTAGONISTS | SANOFI-SYNTHELABO (FR) | 2002-01-29 | — | — | US | disclosed |