Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5701232 | 0.85 | ALDH1A1 (0.45) | ALDH1A1HSD17B10PDE4DTDP1LMNA | |
| SCHEMBL3897270 | 0.83 | MAOA (0.56) | PDE4DPKMMAOAMAOBSLC6A4 | |
| SCHEMBL3894249 | 0.80 | POLB (0.43) | ALDH1A1HSD17B10LMNAPKMTSHR | |
| SCHEMBL3895331 | 0.79 | ESR1 (0.52) | ALDH1A1HSD17B10PDE4DLMNAPKM | |
| SCHEMBL6500345 | 0.75 | MAPT (0.51) | ALDH1A1HSD17B10LMNAPKMMAOB | |
| SCHEMBL21255995 | 0.74 | MAOA (0.66) | PDE4DLMNAPKMMAOAMAOB | |
| SCHEMBL5480307 | 0.74 | MAOA (0.46) | PDE4DMAOAMAOBSLC6A4TSHR | |
| SCHEMBL22782303 | 0.72 | MAOA (0.57) | PDE4DLMNAPKMMAOAMAOB | |
| SCHEMBL3897281 | 0.70 | HRH3 (0.46) | ALDH1A1TDP1LMNAPKMMAOA | |
| SCHEMBL21255908 | 0.70 | MAOA (0.78) | PDE4DLMNAPKMMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005051399-A1 | 7-PHENYLSULFONYL-TETRAHYDRO-3-BENZAZEPINE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2005-06-09 | — | — | WO | disclosed |