Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3894249 | 0.93 | POLB (0.43) | MAPTLMNANPSR1KDM4EALDH1A1 | |
| SCHEMBL6509242 | 0.88 | MAOB (0.54) | MAPTLMNAKDM4EHTR6PKM | |
| Hydrochloric Acid SCHEMBL6504357 | 0.87 | MAOB (0.53) | MAPTLMNAKDM4EHTR6PKM | |
| SCHEMBL6502662 | 0.85 | HTR6 (0.45) | MAPTLMNAHTR6PKMMAOB | |
| SCHEMBL3903162 | 0.81 | MAOB (0.48) | KDM4EHTR6PKMMAOBKMT2A | |
| SCHEMBL6505821 | 0.79 | HTR6 (0.47) | MAPTLMNAALDH1A1HPGDHTR6 | |
| SCHEMBL6510748 | 0.78 | HTR6 (0.46) | ALDH1A1HPGDHSD17B10HTR6PKM | |
| SCHEMBL6502583 | 0.78 | LMNA (0.48) | MAPTLMNANPSR1ALDH1A1HPGD | |
| SCHEMBL6500880 | 0.78 | LMNA (0.51) | MAPTLMNAALDH1A1HTR6PKM | |
| SCHEMBL3893442 | 0.78 | HTR6 (0.49) | HTR6MAOBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014578-A1 | PHENYLSULFONYL COMPOUNDS AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | WO | claimed |
| WO-2005014578-A1 | PHENYLSULFONYL COMPOUNDS AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |