Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625493 | 0.76 | PDE3B (0.43) | RXFP1LMNAPDE3BPDE3A | |
| SCHEMBL625578 | 0.74 | CHEK1 (0.36) | RXFP1LMNAPDE3BPDE3AHSD17B10 | |
| SCHEMBL21435535 | 0.73 | DAO (0.44) | CSNK2A2CSNK2BCSNK2A1RXFP1LMNA | |
| SCHEMBL31731460 | 0.73 | DAO (0.44) | CSNK2A2CSNK2BCSNK2A1RXFP1LMNA | |
| SCHEMBL625475 | 0.73 | PGR (0.57) | RXFP1LMNAMAPT | |
| SCHEMBL625884 | 0.73 | PGR (0.40) | LMNADAO | |
| SCHEMBL626022 | 0.72 | CYP11B1 (0.33) | RXFP1 | |
| SCHEMBL625682 | 0.72 | GRM2 (0.42) | LMNADAO | |
| SCHEMBL31248814 | 0.71 | DAO (0.42) | CSNK2A2CSNK2BCSNK2A1RXFP1LMNA | |
| SCHEMBL31248811 | 0.71 | DAO (0.42) | CSNK2A2CSNK2BCSNK2A1RXFP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |