Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625682 | 0.86 | GRM2 (0.42) | PGRCHEK1DAOLMNAGRM2 | |
| SCHEMBL625475 | 0.86 | PGR (0.57) | PGRLMNA | |
| SCHEMBL625493 | 0.80 | PDE3B (0.43) | CHEK1LMNA | |
| SCHEMBL625578 | 0.78 | CHEK1 (0.36) | PGRCHEK1LMNA | |
| SCHEMBL625825 | 0.76 | METAP2 (0.39) | PGRDAOLMNAGRM2 | |
| SCHEMBL627637 | 0.75 | PDE2A (0.44) | CHEK1LMNAPIK3CDPIK3CAPIK3CB | |
| SCHEMBL624871 | 0.73 | CSNK2A2 (0.36) | DAOLMNA | |
| SCHEMBL625351 | 0.66 | GRM2 (0.76) | GRM2HSD17B2CYP3A4CYP2C9HSD17B1 | |
| SCHEMBL23601556 | 0.65 | PGR (0.45) | PGRDAOLMNACYP2C9 | |
| SCHEMBL24721347 | 0.63 | PGR (0.43) | PGRDAOLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |