Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625884 | 0.83 | PGR (0.40) | — | |
| SCHEMBL625493 | 0.81 | PDE3B (0.43) | RXFP1 | |
| SCHEMBL627637 | 0.76 | PDE2A (0.44) | PRMT5WDR77 | |
| SCHEMBL625578 | 0.74 | CHEK1 (0.36) | RXFP1 | |
| SCHEMBL625682 | 0.74 | GRM2 (0.42) | GRIN1GRIN2B | |
| SCHEMBL625475 | 0.74 | PGR (0.57) | GRIN1GRIN2BRXFP1 | |
| SCHEMBL624871 | 0.72 | CSNK2A2 (0.36) | RXFP1 | |
| SCHEMBL625825 | 0.71 | METAP2 (0.39) | RXFP1 | |
| SCHEMBL627105 | 0.70 | METAP2 (0.41) | CYP11B2RXFP1 | |
| SCHEMBL625999 | 0.68 | BRD4 (0.35) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | claimed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | claimed |