Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625884 | 0.86 | PGR (0.40) | PGRLMNA | |
| SCHEMBL625682 | 0.84 | GRM2 (0.42) | PGRGRIN1GRIN2BLMNA | |
| SCHEMBL625825 | 0.81 | METAP2 (0.39) | PGRMAPTMAOBRXFP1LMNA | |
| SCHEMBL625493 | 0.80 | PDE3B (0.43) | RXFP1LMNA | |
| SCHEMBL625578 | 0.78 | CHEK1 (0.36) | PGRRXFP1LMNA | |
| SCHEMBL627637 | 0.75 | PDE2A (0.44) | LMNA | |
| SCHEMBL6540944 | 0.73 | PGR (1.00) | PGRMAPTMAOBMAOALMNA | |
| SCHEMBL624871 | 0.73 | CSNK2A2 (0.36) | MAPTRXFP1LMNA | |
| SCHEMBL627135 | 0.68 | LMNA (0.40) | PGRMAPTMAOBGRIN1GRIN2B | |
| SCHEMBL10146602 | 0.66 | GRM2 (0.76) | PGRMAOBMAOAGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | claimed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | claimed |