Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2257063 | 0.91 | LRRK2 (0.31) | — | |
| SCHEMBL626842 | 0.82 | FYN (0.30) | — | |
| SCHEMBL626840 | 0.82 | FYN (0.30) | — | |
| SCHEMBL623858 | 0.82 | IRAK4 (0.33) | IRAK4 | |
| SCHEMBL624134 | 0.77 | NPY5R (0.35) | — | |
| SCHEMBL626163 | 0.77 | HSD11B1 (0.32) | HSD11B1IRAK4 | |
| SCHEMBL625010 | 0.77 | HSD11B1 (0.35) | HSD11B1IRAK4 | |
| SCHEMBL625281 | 0.75 | PIK3CA (0.52) | PIM1KCNH2 | |
| SCHEMBL627849 | 0.75 | FYN (0.46) | PIM1KCNH2IRAK4 | |
| SCHEMBL15324840 | 0.74 | LMNA (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |