SCHEMBL6250179 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	OPRK1	P41145	8/20	0.55

▸	CYP2D6	P10635	7/20	0.55

▸	ALDH1A1	P00352	3/20	0.38

▸	LMNA	P02545	1/20	0.38

▸	SIGMAR1	Q99720	2/20	0.37

▸	WDR5	P61964	1/20	0.37

▸	MEN1	O00255	1/20	0.36

▸	MAPT	P10636	1/20	0.36

▸	KMT2A	Q03164	1/20	0.36

▸	POLB	P06746	1/20	0.35

▸	HTT	P42858	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6250215	0.89	OPRK1 (0.50)	OPRK1CYP2D6
SCHEMBL6252280	0.86	OPRK1 (0.42)	OPRK1CYP2D6
SCHEMBL6250833	0.85	OPRK1 (0.54)	OPRK1CYP2D6ALDH1A1KMT2A
SCHEMBL6247456	0.85	OPRK1 (0.54)	OPRK1CYP2D6
SCHEMBL6248817	0.85	OPRK1 (0.54)	OPRK1CYP2D6
SCHEMBL6249594	0.83	OPRK1 (0.55)	OPRK1CYP2D6LMNAMEN1MAPT
SCHEMBL6250186	0.82	OPRK1 (0.57)	OPRK1CYP2D6
SCHEMBL6247648	0.82	OPRK1 (0.57)	OPRK1CYP2D6
SCHEMBL16333376	0.81	SIGMAR1 (0.57)	OPRK1ALDH1A1LMNASIGMAR1MEN1
SCHEMBL6249600	0.79	CYP2D6 (0.56)	OPRK1CYP2D6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2005049564-A1	AMIDE DERIVATIVES AND METHODS OF THEIR USE	ADOLOR CORPORATION (US)	2005-06-02	—	—	WO	disclosed