Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10358733 | 0.86 | SIGMAR1 (0.69) | SIGMAR1KMT2AALDH1A1LMNAOPRK1 | |
| Hydrochloric Acid SCHEMBL10359115 | 0.85 | SIGMAR1 (0.68) | SIGMAR1KMT2AALDH1A1LMNAOPRK1 | |
| SCHEMBL16333323 | 0.84 | OPRK1 (0.40) | SIGMAR1KMT2AOPRK1MEN1SIRT2 | |
| SCHEMBL8701795 | 0.84 | LTB4R (0.43) | SIGMAR1OPRK1 | |
| SCHEMBL6250179 | 0.81 | OPRK1 (0.55) | SIGMAR1KMT2AALDH1A1LMNAOPRK1 | |
| SCHEMBL16973901 | 0.80 | CTSB (0.48) | SIGMAR1KMT2AALDH1A1LMNAOPRK1 | |
| SCHEMBL8704031 | 0.79 | MAPT (0.38) | SIGMAR1KMT2AALDH1A1OPRK1MEN1 | |
| SCHEMBL8702756 | 0.79 | OPRM1 (0.46) | SIGMAR1OPRK1 | |
| SCHEMBL16333452 | 0.78 | KCNH2 (0.47) | SIGMAR1OPRK1 | |
| SCHEMBL6249500 | 0.78 | OPRK1 (0.49) | KMT2AOPRK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013812-A2 | KAPPA OPIOID AGONISTS AND USES THEREOF | Nektar Therapeutics (US) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014210436-A2 | KAPPA OPIOID AGONISTS AND USES THEREOF | NEKTAR THERAPEUTICS (US) | 2014-12-31 | — | — | WO | disclosed |