Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | GRK5 | P34947 | 1/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30486108 | 0.80 | BRAF (0.61) | KDRRETCDK8MAP4K2TTBK1 | |
| SCHEMBL4912546 | 0.76 | ERBB2 (0.44) | KDRAURKBDAPK3MAP4K4PRKACA | |
| SCHEMBL2999856 | 0.75 | AURKB (0.51) | KDRJAK2AURKBIKBKBCHUK | |
| SCHEMBL30564548 | 0.75 | TRPA1 (0.63) | JAK2AURKBCSF1RJAK3TTBK1 | |
| SCHEMBL31193701 | 0.75 | IKBKB (0.40) | KDRAURKBIKBKBCHUKROCK1 | |
| SCHEMBL29424797 | 0.73 | BRD4 (0.60) | KDRJAK2AURKBIKBKBCHUK | |
| SCHEMBL298491 | 0.73 | BRD4 (0.60) | KDRJAK2AURKBIKBKBCHUK | |
| SCHEMBL858031 | 0.72 | TNNI3K (0.58) | KDRJAK2AURKBIKBKBCHUK | |
| SCHEMBL31193705 | 0.72 | ROCK2 (0.42) | AURKBDAPK3CSF1RPRKACACDK8 | |
| SCHEMBL2310574 | 0.71 | NUDT1 (0.49) | KDRJAK2AURKBIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562935-A1 | HETEROARYLOXY-SUBSTITUTED PHENYLAMINOPYRIMIDINES AS RHO-KINASE INHIBITORS | Bayer HealthCare AG (DE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004039796-A1 | HETEROARYLOXY-SUBSTITUTED PHENYLAMINOPYRIMIDINES AS RHO-KINASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2004-05-13 | — | — | WO | disclosed |