SCHEMBL6250316

SCHEMBL6250316

N#CN(C(N)=O)C(=O)[CH]Cc1nccs1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FDPS P14324 1/20 0.36
TRPM8 Q7Z2W7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14167174 0.76 FDPS (0.46) FDPSTRPM8
SCHEMBL6021436 0.70 ALDH1A1 (0.37)
SCHEMBL6019621 0.69 CA2 (0.40)
Carbamic Acid SCHEMBL2360596 0.68 FDPS (0.41) FDPS
SCHEMBL291398 0.66 MAPT (0.43) FDPSTRPM8
SCHEMBL6406136 0.66 TTR (0.34)
SCHEMBL474771 0.64
SCHEMBL21694389 0.63 FDPS (0.42) FDPSTRPM8
SCHEMBL1005554 0.63
SCHEMBL247632 0.63

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1569954-A1 CYANOMETHYL DERIVATIVES AS CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2005-09-07 EP disclosed
WO-2004052921-A1 CYANOMETHYL DERIVATIVES AS CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-06-24 WO disclosed